Fort L., Vamadevan V., Wang W., Macara I.G. Actomyosin contractility is a potent inhibitor of mesoderm induction by human pluripotent stem cells. bioRxiv doi.org/10.1101/2024.09.30.615859 (co-corresponding author) (Under revision at J. Cell Biol) [ hyperlink ]
Nikolaou S., Juin A., Whitelaw J.A., Paul, N.R., Fort L., Nixon C., Spence H.J., Bryson S., Machesky L.M. CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. eLife (2024) doi.org/10.7554/eLife.83712 (Peer-reviewed research article) [ hyperlink ]
Whitelaw J.A., Lilla S., Nikolaou S., Tweedy L., Fort L., Paul N., Zanivan S., Gadegaard N., Insall R.H., Machesky L.M. CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge. bioRxiv https://doi.org/10.1101/2024.03.26.586838 (Under revision at J. Cell Sci.) [ hyperlink ]
Fort L. Messenger functions of cell death during development and homeostasis. Biochem Soc Trans 51 (2): 759–769 (2023) doi.org/10.1042/BST20220925 [ hyperlink ]
Fort L., Gama V., Macara I.G. Stem cell conversion to the cardiac lineage requires nucleotide signaling from apoptosing cells. Nat. Cell Biol. 24, 434-447 (2022). doi.org/10.1038/s41556-022-00888-x [ hyperlink ]
Le A., Yelland T., Paul N.R., Fort L., Nikalaou S., Ismail S., Machesky L.M. CYRI-A limits invasive migration through macropinosome formation and integrins uptake regulation. J. Cell Biol. 220 (9) doi.org/10.1083/jcb.202012114 [ hyperlink ]
Juin A., Spence H. J., Martin K. J. M., McGhee E., Neilson M., Cutiongco M. F. A., Gadegaard N., Mackay G., Fort L., Lilla S., Kalna G., Thomason P. A., Koh Y. W. H., Norman J. C., Insall R. H., Machesky L. M. N-WASP control of LPAR1 trafficking establishes response to self-generated LPA gradients to promote pancreatic cancer cell metastasis. Dev. Cell 51, 431-445. doi: 10.1016/j.devcel.2019.09.018 [ hyperlink ]
Whitelaw J.A., Lilla.S., Paul N.R., Fort L., Zanivan S., Machesky L.M. CYRI proteins represent a new class of Rac1 interactors. Comm. Integr. Biol. 12 (1) 112-118. doi: 10.1080/19420889.2019.1643665 [ hyperlink ]
Fort L*., Batista J*., Thomason P.A., Spence H. J., Whitelaw J.A., Tweedy L., Greaves J., Martin K. J., Anderson K. I., Brown P., Lilla S., Neilson M.P., Tafelmeyer P., Zanivan S., Ismail S., Bryant D. M., Tomkinson N. C. O., Chamberlain L. H., Mastick G. S., Insall R. H., Machesky L. M. Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nat. Cell Biol. 20 (10) : 1159-1171 doi: 10.1038/s41556-018-0198-9 (* Authors contributed equally) [ hyperlink ]
Morris H.T., Fort L., Spence H. J., Patel R., Vincent D. F., Park J.H., Snapper S.B., Carey F.A., Sansom O., Machesky L. M. Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. J Pathol. 245 (3) 337-348. doi: 10.1002/path.5086 [ hyperlink ]
Giampazolias E., Zunino B., Dhayade S., Bock F., Cloix C., Cao K., Roca A., Lopez J., Ichim G., ProÔcs E., Rubio-PatiÒo C., Fort L., Yatim N., Woodham E., Orozco S., Taraborelli L., Peltzer N., Lecis D., Machesky L.M, Walczak H., Albert M., Milling S., Oberst A., Ricci J.E., Ryan K., Blyth K., Tait S. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat. Cell Biol. 19 (9) : 1116-1129 doi: 10.1038/ncb3596 [ hyperlink ]
Nivon M., Fort L., Muller P., Richet E., Simon S., Guey B., Fournier M., Arrigo A.P., Hetz C., Atkin J.D., Kretz-Remy C. NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation. Mol. Biol. Cell. 27 (11) : 1712-27 doi: 10.1091/mbc.E15-12-0835 [ hyperlink ]